AI Bioinformatics Engineering Lead

The opportunity

What you'll own

• Own gene, disease, and variant mapping logic in the AI system.
• Design and maintain how genomic data is used and interpreted in AI workflows.
• Define approaches for handling complex and edge-case genomic scenarios.
• Set measurable accuracy thresholds for AI-powered features.
• Define release criteria that AI features must meet before going live.
• Lead the overall evaluation and benchmarking strategy for AI outputs.
• Establish regression standards so future changes preserve or improve accuracy.
• Partner with the AI Bioinformatics Benchmarking Engineer on automated validation.
• Approve validation criteria that determine when AI features are ready for release.
• Work closely with AI, Bioinformatics, Product, and Engineering leaders on system design.
• Recommend where deterministic logic should supplement model behavior in production.
• Ensure interpretation logic can be maintained and updated as new genomic knowledge appears.

Who you are

• Advanced degree in Bioinformatics, Computational Biology, or a closely related field.
• Strong experience with VCFs and complex genomic datasets.
• Familiarity with ClinVar, dbSNP, HGVS standards, transcript databases, and variant classification.
• Systems-level leadership that defines standards and frameworks for correctness.
• Experience working with production software engineering teams.
• Experience collaborating with AI or LLM-based systems.
• Experience setting or contributing to evaluation and benchmarking frameworks.
• Comfortable working fully remote as part of a distributed team.

Benefits Overview

• Comprehensive medical, dental, and vision insurance coverage
• 401(k) with company matching
• Paid time off (PTO)
• Paid volunteer time off
• Fully remote work with home office stipend
• Parental bonding leave
• Clinical-grade whole genome sequencing for you and your family (private and confidential)

Join Sequencing

• Redefine how people understand themselves through their DNA
• Build category-defining products alongside scientists, engineers, and innovators
• Contribute to technology that will improve and extend millions of lives
• Shape one of the most important emerging categories in AI and healthcare