AI Chief Of Staff

The Position 

The Impact 

• Drive company execution against strategic priorities by partnering with the CEO, COO, and leadership team to translate strategy into clear plans, ensure alignment, and maintain momentum on the highest-impact initiatives
• Act as a force multiplier for the CEO and COO, helping prioritize focus, structure key decisions, and ensure follow-through on critical initiatives and cross-functional workstreams
• Identify and implement opportunities to use AI agents, automation, and lightweight systems to improve internal workflows, productivity, and cross-functional execution across Operations, Finance, Customer Success, and other teams.
• Build and run the company’s operating system, including leadership cadences, planning and review cycles, and decision-making frameworks that improve clarity, accountability, and speed across teams
• Own goal-setting and performance management (OKRs), ensuring tight alignment from company priorities to team execution, surfacing risks early, and driving accountability for results
• Drive cross-functional alignment and unblock execution, working across Product, Bioinformatics, Engineering and Marketing teams to resolve conflicts, clarify ownership, and keep initiatives moving
• Build and scale a centralized vendor and procurement function, standardizing vendor selection, contract negotiation, approval workflows, and renewal tracking across external labs, 3PL, SaaS/AI tools, and other partners to reduce risk, improve speed, and optimize spend
• Lead high-priority, ambiguous projects end-to-end, from problem definition through execution, particularly in areas critical to scaling the business
• Support resource planning and scaling efforts, partnering with Finance and leadership on budgeting, headcount planning, and ensuring strategic priorities are properly resourced

Dominant and Expressed Traits 

• 5+ years in consulting, strategy, or business operations with a track record of owning complex, cross-functional initiatives from definition through execution
• Experience operating in a fast-moving startup or similarly dynamic environment, with the ability to adapt quickly while maintaining focus on outcomes
• Exceptional organizational and execution skills, with the ability to manage multiple high-stakes workstreams and consistently drive them to completion
• Demonstrated fluency with AI tools, agents, and workflow automation, with a track record of using emerging technologies to create leverage, reduce manual work, and improve team productivity
• Proven ability to build and implement operating systems (e.g., planning cadences, OKRs, reporting, decision frameworks) that teams adopt and rely on
• Strong written and verbal communicator, capable of producing clear, executive-ready materials that drive alignment and decision-making
• High judgment and low ego: able to partner closely with senior leaders, push for clarity, and hold teams accountable while maintaining trust
• Systems thinker who uses process, tools, and data to improve speed, transparency, and reliability of execution
• Intellectual curiosity and comfort with technical domains; interest in genomics, health data, or complex data-driven products is strongly preferred

Benefits Overview

• Comprehensive medical, dental, and vision insurance coverage
• 401(k) with company matching
• Paid time off (PTO)
• Paid volunteer time off
• Fully remote work with home office stipend
• Parental bonding leave
• Clinical-grade whole genome sequencing for you and your family (private and confidential)

Join Sequencing

• Redefine how people understand themselves through their DNA
• Build category-defining products alongside scientists, engineers, and innovators
• Contribute to technology that will improve and extend millions of lives
• Shape one of the most important emerging categories in AI and healthcare