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- Seniority
- Lead
About the role
<div class="content-intro"><p>Centessa Pharmaceuticals plc (Nasdaq: CNTA) new kind of pharmaceutical company with a deconstructed R&D environment that prioritizes data driven decision making led by subject matter experts. Centessa is advancing a portfolio of high conviction programs with strong biological validation.</p>
<p>Our asset-centric model offers a unique R&D logic that has been applied by single asset companies to improve productivity. This operating model has minimal centralized infrastructure, reduced hierarchy, and exclusive focus on data driven capital allocation. Our teams are uniquely incentivized to expeditiously interrogate key scientific hypotheses. We believe the asset-centric model can lead to improved success rates for programs with greater speed and modest costs.</p>
<p> </p></div><p><strong>Description of Role</strong></p>
<p>Centessa is seeking an experienced Senior Director, Clinical Pharmacology to provide scientific and strategic leadership for clinical pharmacology across a diverse pipeline spanning early development through late-stage and registrational programs. Reporting to the Executive Director, Clinical Pharmacology, this position is accountable for developing and executing clinical pharmacology strategies that address the unique challenges of neuroscience drug development, including CNS exposure, dose optimization, and translational relevance. The Senior Director partners closely with cross-functional teams and represents clinical pharmacology in regulatory interactions to enable efficient, data-driven advancement of therapies across our neuroscience portfolio.</p>
<p><strong>Key Responsibilities</strong></p>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1"><span data-contrast="none">Lead clinical pharmacology strategy for CNS and neuroscience programs from </span><span data-contrast="auto">first</span>‑<span data-contrast="auto">in</span>‑<span data-contrast="auto">human through registrational and post</span>‑<span data-contrast="auto">marketing stages </span></li>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1">Design, execute, and interpret clinical pharmacology studies, including FIH, multiple‑<span data-contrast="auto">ascending dose, DDI, biopharmaceutics, and patient studies </span></li>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1">Drive dose selection and optimization by integrating PK, PD, safety, efficacy, and CNS‑<span data-contrast="auto">specific biomarkers </span><span data-ccp-props="{}"> </span></li>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1">Lead model‑<span data-contrast="auto">informed drug development, including population PK, PK/PD, and exposure–response analyses relevant to CNS targets and clinical safety</span></li>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1">Assess and guide strategies for CNS exposure, brain penetration, target engagement, and translational biomarkers <span data-ccp-props="{}"> </span></li>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1">Serve as the clinical pharmacology lead on program teams, clinical sub‑<span data-contrast="auto">teams, and trial working groups </span></li>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1">Author and oversee clinical pharmacology sections of regulatory documents (e.g., INDs, CTAs, IBs, NDAs) <span data-ccp-props="{}"> </span></li>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1">Represent clinical pharmacology in interactions with FDA and other global health authorities, supporting dose justification and labeling discussions <span data-ccp-props="{}"> </span></li>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1">Partner closely with DMPK, Translational Sciences, Clinical Development, Biomarkers, Biostatistics, CMC, and Regulatory Affairs <span data-ccp-props="{}"> </span></li>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1">Oversee CROs and external vendors conducting clinical pharmacology and modeling activities <span data-ccp-props="{}"> </span></li>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1">Ensure timely communication and clear interpretation of clinical pharmacology results to internal stakeholders </li>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1">Contribute to portfolio strategy, program prioritization, risk mitigation, and long‑<span data-contrast="auto">range clinical development planning for CNS assets </span></li>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1">Serve as a subject‑<span data-contrast="auto">matter expert on clinical pharmacology </span></li>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1">Mentor and develop clinical pharmacology talent as the pipeline and organization grow <span data-ccp-props="{}"> </span></li>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1">Ensure high‑<span data-contrast="auto">quality, submission</span>‑<span data-contrast="auto">ready documentation aligned with global regulatory standards</span><span data-ccp-props="{}"> </span></li>
</ul>
<p><strong>Qualifications</strong></p>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="16" data-aria-level="1"><span data-contrast="auto">PhD, PharmD, or MD in Clinical Pharmacology, Pharmacokinetics, Pharmaceutical Sciences, or a related discipline </span></li>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="16" data-aria-level="1">8–12+ years of experience in clinical pharmacology within biopharma, with demonstrated impact in clinical drug development </li>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="16" data-aria-level="1">Extensive experience developing and executing clinical pharmacology strategies for early‑<span data-contrast="auto"> through late</span>‑<span data-contrast="auto">stage programs, including registrational support </span></li>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="16" data-aria-level="1">Strong expertise in PK, PD, PK/PD integration, exposure–response analyses, and drug–drug interaction assessment </li>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="16" data-aria-level="1">Demonstrated experience applying quantitative clinical pharmacology approaches (e.g., population PK, mechanistic PK/PD modeling) to inform CNS dose selection and optimization <span data-ccp-props="{}"> </span></li>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="16" data-aria-level="1">Proficiency with clinical pharmacology tools and platforms such as NONMEM, R, Phoenix WinNonlin, SimCyp, or equivalent </li>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="16" data-aria-level="1">Experience authoring and delivering clinical pharmacology components of regulatory submissions (e.g., INDs, CTAs, NDAs) and interacting with global health authorities <span data-ccp-props="{}"> </span></li>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="16" data-aria-level="1">Strong understanding of translational PK, CNS exposure considerations, and biomarker integration in neuroscience drug development <span data-ccp-props="{}"> </span></li>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="16" data-aria-level="1">Excellent communication, collaboration, and leadership skills with the ability to operate effectively in a fast‑<span data-contrast="auto">paced, matrixed environment</span><span data-ccp-props="{}"> </span></li>
</ul>
<p><strong><span data-contrast="auto">Compensation</span></strong><span data-ccp-props="{}"> </span></p>
<p><span data-contrast="auto">The annual base salary range for this position is $270,000.00 to $295,000.00. Individual compensation within this range will be determined based on a variety of factors, including qualifications, skills, relevant experience, and job knowledge.</span><span data-ccp-props="{}"> </span></p>
<p><span data-contrast="auto">In addition to base pay, this role is eligible for a discretionary annual bonus.</span> <span data-contrast="auto">Centessa also offers a comprehensive benefits package, which includes a 401(k) plan, company-sponsored medical, dental, vision, and life insurance, generous paid time off, and a health and wellness program.</span><span data-ccp-props="{}"> </span></p>
<p><strong>Work Location</strong></p>
<p><span class="TextRun SCXW102698544 BCX0" lang="EN-US" data-contrast="auto"><span class="NormalTextRun SCXW102698544 BCX0" data-ccp-parastyle="Normal (Web)">The </span><span class="NormalTextRun SCXW102698544 BCX0" data-ccp-parastyle="Normal (Web)">Senior Director, Clinical </span><span class="NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW102698544 BCX0" data-ccp-parastyle="Normal (Web)">Pharmacology</span><span class="NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW102698544 BCX0" data-ccp-parastyle="Normal (Web)"> role</span><span class="NormalTextRun SCXW102698544 BCX0" data-ccp-parastyle="Normal (Web)"> is a remote role based in the US, with occasional travel</span><span class="NormalTextRun SCXW102698544 BCX0" data-ccp-parastyle="Normal (Web)">.</span></span><span class="EOP SCXW102698544 BCX0" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335557856":16777215,"335559738":0,"335559739":360,"335559740":240}"> </span></p>
<p><strong>POSITION:</strong> Full-Time, Exempt</p><div class="content-conclusion"><p>EEOC Statement: Centessa Pharmaceuticals believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion, or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Centessa Pharmaceuticals will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.</p>
<p><strong><span class="break-words
tvm-parent-container">Please note: We will not assign referral rights for any unsolicited resumes from recruitment agencies.</span></strong></p>
<p><strong><span class="break-words
tvm-parent-container"><img src="https://centessa.hosted-by-files.com/CorpImages/Centessa_Pharmaceuticals_LLC_US_English_2026_Certification_Badge.png" alt="Great Place to Work Certificate" width="248" style="max-width: 100%;"></span></strong></p></div>
Perks & benefits
- 401k
- Paid Time Off
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