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- Seniority
- Lead
About the role
<div class="content-intro"><p>Centessa Pharmaceuticals plc (Nasdaq: CNTA) new kind of pharmaceutical company with a deconstructed R&D environment that prioritizes data driven decision making led by subject matter experts. Centessa is advancing a portfolio of high conviction programs with strong biological validation.</p>
<p>Our asset-centric model offers a unique R&D logic that has been applied by single asset companies to improve productivity. This operating model has minimal centralized infrastructure, reduced hierarchy, and exclusive focus on data driven capital allocation. Our teams are uniquely incentivized to expeditiously interrogate key scientific hypotheses. We believe the asset-centric model can lead to improved success rates for programs with greater speed and modest costs.</p>
<p> </p></div><p><strong>Description of Role</strong></p>
<p><span class="TextRun SCXW217269077 BCX0" lang="EN-US" data-contrast="auto"><span class="NormalTextRun SCXW217269077 BCX0">Centessa</span><span class="NormalTextRun SCXW217269077 BCX0"> is seeking </span><span class="NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW217269077 BCX0">an Associate</span><span class="NormalTextRun SCXW217269077 BCX0"> Director</span><span class="NormalTextRun SCXW217269077 BCX0">, Small Molecule Drug Substance Process Chemistry. The successful candidate will work closely with their management in directing CDMOs to develop and implement strategies to deliver advanced chemical intermediates and active pharmaceutical ingredients for use in research, </span><span class="NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW217269077 BCX0">GLP</span><span class="NormalTextRun SCXW217269077 BCX0"> and cGMP studies. This individual will work with several internal departments and third-party procurement and distribution providers to align </span><span class="NormalTextRun SCXW217269077 BCX0">objectives</span><span class="NormalTextRun SCXW217269077 BCX0"> and drive decision-making related to process chemistry and manufacturing. This person will drive the execution of assigned process chemistry activities of </span><span class="NormalTextRun SpellingErrorV2Themed SCXW217269077 BCX0">Centessa’s</span><span class="NormalTextRun SCXW217269077 BCX0"> small molecule pipeline. Travel to vendors both domestically and internationally may be </span><span class="NormalTextRun SCXW217269077 BCX0">required</span><span class="NormalTextRun SCXW217269077 BCX0">.</span></span><span class="EOP SCXW217269077 BCX0" data-ccp-props="{}"> </span></p>
<p><strong>Key Responsibilities</strong></p>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1"><span data-contrast="auto">Direct CDMO team(s) in manufacturing of advanced chemical intermediates and APIs for GLP studies as well as early and late stage clinical studies. </span></li>
<li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1">Review, approve and issue manufacturing batch records.</li>
<li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1">Collaborate with CRO/CDMOs and expert consultants to address process chemistry challenges and develop manufacturing processes that are scalable, safe and cost-effective.</li>
<li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1">Support contractor sites via meeting updates, remote and on-site involvement pertaining to OOS/OOT, investigations/deviations, and other pertinent documentation. In addition, provide on-site presence during active manufacturing campaigns, as needed.</li>
<li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1">Prepare presentation materials and clearly communicate progress, challenges and potential risk in API manufacturing to management in real time or weekly basis, as needed.</li>
<li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1">Author and review technical reports, tech transfer packages, and GMP production records as well as CMC sections regulatory related documentation (ie. INDs) submission, and any documents related to intellectual property.</li>
<li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1">Assist with new vendor assessment and selection by providing technical review of CDMO resources, capacities, and capabilities as appropriate for development needs.</li>
<li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1">Aid with plans for technology transfers of drug substances from one supplier to new suppliers.</li>
<li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1">Build and maintain strong relationships with internal and external stakeholders; proactively seek buy-in and provide on-going support to address business needs.</li>
<li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1">Escalate and cascade information as needed with discretion.<strong><span data-contrast="auto"> </span></strong><span data-ccp-props="{}"> </span></li>
</ul>
<p><strong>Qualifications</strong></p>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="11" data-aria-level="1"><span data-contrast="auto">PhD in Chemistry, Chemical Engineering, Pharmaceutical Sciences, or a related discipline or MS with extensive relevant biotech/pharmaceutical industry experience</span></li>
<li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="11" data-aria-level="1">10+ years of experience in biotech/pharmaceutical industry <span data-contrast="none">in small molecules, working in early to late development (pre-clinical to phase 3)</span></li>
<li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="11" data-aria-level="1">Extensive experience in process chemistry development, scale-up, tech transfer and process characterizations, as well as deep understanding of GMP/GLP regulations.</li>
<li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="11" data-aria-level="1">Demonstrated experience with managing project teams, CDMOs and other vendors.</li>
<li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="11" data-aria-level="1">Proven expertise in process chemistry and early and late stages API manufacturing and ability to coordinate CDMO activities in the development and commercialization of pharmaceutical products.</li>
<li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="11" data-aria-level="1">Thorough understanding of cGMP requirements for pharmaceutical products. Ability to work</li>
<li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="11" data-aria-level="1">Ability to work independently in a fast-paced dynamic environment with multiple projects.</li>
<li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="11" data-aria-level="1">Strong analytical, organizational and decision-making skills. </li>
<li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="11" data-aria-level="1">Excellent communication skills, both written, verbal </li>
<li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="11" data-aria-level="1">Must be willing to travel both domestically and internationally approximately 15% - 20% of the time. <span data-ccp-props="{}"> </span></li>
</ul>
<p><strong><span data-contrast="auto">Compensation</span></strong><span data-ccp-props="{}"> </span></p>
<p><span data-contrast="auto">The annual base salary range for this position is $185,000.00 to $200,000.00. Individual compensation within this range will be determined based on a variety of factors, including qualifications, skills, relevant experience, and job knowledge.</span><span data-ccp-props="{}"> </span></p>
<p><span data-contrast="auto">In addition to base pay, this role is eligible for a discretionary annual bonus. Centessa also offers a comprehensive benefits package, which includes a 401(k) plan, company-sponsored medical, dental, vision, and life insurance, generous paid time off, and a health and wellness program.</span></p>
<p><strong>Work Location</strong></p>
<p><span class="TextRun SCXW107147065 BCX0" lang="EN-US" data-contrast="auto"><span class="NormalTextRun SCXW107147065 BCX0" data-ccp-parastyle="Normal (Web)">The </span><span class="NormalTextRun SCXW107147065 BCX0" data-ccp-parastyle="Normal (Web)">Associate Director, Drug Substance</span><span class="NormalTextRun SCXW107147065 BCX0" data-ccp-parastyle="Normal (Web)"> </span><span class="NormalTextRun SCXW107147065 BCX0" data-ccp-parastyle="Normal (Web)">CMC role is</span><span class="NormalTextRun SCXW107147065 BCX0" data-ccp-parastyle="Normal (Web)"> based in the US, with occasional travel</span><span class="NormalTextRun SCXW107147065 BCX0" data-ccp-parastyle="Normal (Web)"> (15% - 20%)</span><span class="NormalTextRun SCXW107147065 BCX0" data-ccp-parastyle="Normal (Web)">.</span></span><span class="EOP SCXW107147065 BCX0" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335557856":16777215,"335559738":0,"335559739":360,"335559740":240}"> </span></p>
<p><strong>POSITION:</strong> Full-Time, Exempt</p>
<p> </p><div class="content-conclusion"><p>EEOC Statement: Centessa Pharmaceuticals believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion, or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Centessa Pharmaceuticals will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.</p>
<p><strong><span class="break-words
tvm-parent-container">Please note: We will not assign referral rights for any unsolicited resumes from recruitment agencies.</span></strong></p>
<p><strong><span class="break-words
tvm-parent-container"><img src="https://centessa.hosted-by-files.com/CorpImages/Centessa_Pharmaceuticals_LLC_US_English_2026_Certification_Badge.png" alt="Great Place to Work Certificate" width="248" style="max-width: 100%;"></span></strong></p></div>
Perks & benefits
- 401k
- Paid Time Off
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