Executive Director, Head of Toxicology

<div class="content-intro"><p>Centessa Pharmaceuticals plc (Nasdaq: CNTA) new kind of pharmaceutical company with a deconstructed R&amp;D environment that prioritizes data driven decision making led by subject matter experts. Centessa is advancing a portfolio of high conviction programs with strong biological validation.</p> <p>Our asset-centric model offers a unique R&amp;D logic that has been applied by single asset companies to improve productivity. This operating model has minimal centralized infrastructure, reduced hierarchy, and exclusive focus on data driven capital allocation. Our teams are uniquely incentivized to expeditiously interrogate key scientific hypotheses. We believe the asset-centric model can lead to improved success rates for programs with greater speed and modest costs.</p> <p>&nbsp;</p></div><p><strong>Description of Role</strong></p> <p><span data-contrast="auto">Centessa Pharmaceuticals is seeking&nbsp;an&nbsp;Executive Director/Head of Toxicology&nbsp;to&nbsp;provide&nbsp;scientific and strategic leadership for nonclinical safety across discovery and development programs, with an emphasis on&nbsp;small</span>‑<span data-contrast="auto">molecule&nbsp;therapeutics. This role leads toxicology and safety pharmacology strategy to support target&nbsp;selection, lead optimization,&nbsp;IND</span>‑<span data-contrast="auto">enabling&nbsp;activities, and clinical advancement. Reporting&nbsp;to our&nbsp;SVP, Nonclinical &amp; Translational Development</span><strong><em><span data-contrast="auto">,&nbsp;</span></em></strong><span data-contrast="auto">the&nbsp;Head of Toxicology partners closely with&nbsp;cross</span>‑<span data-contrast="auto">functional&nbsp;teams and&nbsp;represents&nbsp;nonclinical safety in regulatory interactions while building a strong,&nbsp;high</span>‑<span data-contrast="auto">performing&nbsp;toxicology organization.</span><span data-ccp-props="{}">&nbsp;</span></p> <p><strong>Key Responsibilities</strong></p> <ul> <li>Lead and mentor a team of toxicologists and technical/operational staff, fostering scientific excellence and professional growth</li> <li>Define and execute nonclinical safety strategies across discovery, preclinical, and clinical stages</li> <li>Provide expert toxicology and safety pharmacology input to cross‑functional development teams</li> <li>Lead nonclinical sub‑teams as an integrated development head, providing cross‑functional oversight across Toxicology, DMPK, Bioanalytical Sciences, and Clinical Pharmacology to ensure aligned, program‑ready nonclinical strategies</li> <li>Serve as the primary nonclinical representative on Program Development Teams (PDTs) and at internal governance and external forums, effectively championing program strategy, presenting to regulatory authorities, and holding scientific ground with senior leadership, partners, CROs, and health authorities</li> <li>Design, oversee, and interpret GLP, non‑GLP, investigative, and in vitro toxicology studies</li> <li>Develop safety strategies for new targets, lead optimization programs, and platform technologies</li> <li>Oversee toxicology and safety pharmacology studies conducted internally and at CROs</li> <li>Ensure high scientific quality, compliance, and timely delivery of nonclinical study outputs</li> <li>Author and critically review toxicology sections of regulatory documents (e.g., pre‑IND, IND, IBs)</li> <li>Partner with biology, DMPK, pathology, pharmacology, clinical, and regulatory colleagues to drive integrated decision‑making</li> <li>Present nonclinical safety data and risk assessments to project teams and senior R&amp;D leadership</li> <li>Serve as the primary nonclinical safety representative in regulatory agency interactions</li> <li>Support product defense and regulatory submissions through robust scientific rationale</li> <li>Provide strategic guidance on safety issue resolution and investigational toxicology approaches</li> <li>Contribute to portfolio‑level planning and prioritization of nonclinical safety resources</li> <li>Build scalable toxicology capabilities to support a growing and diverse pipeline</li> </ul> <p><strong>Qualifications</strong></p> <ul> <li>PhD in Toxicology, Pharmacology, Pathology, DVM, or related discipline; board certification (e.g., DABT, ERT) - required</li> <li>18+ years of experience in pharmaceutical or biotechnology R&amp;D with a strong track record in nonclinical and regulatory toxicology</li> <li>Proven ability to function as an upward‑facing nonclinical leader and generalist, with the credibility and judgment to represent project development team agenda at decisional governance meetings, engage confidently with regulatory agencies, and serve as a trusted development partner to senior leadership</li> <li>Deep expertise supporting small‑molecule programs across discovery, IND‑enabling, and early clinical development</li> <li>Strong working knowledge of national and international GLP guidelines</li> <li>Demonstrated experience defining and executing nonclinical safety strategies to support diverse pipelines and novel biology</li> <li>Proven leadership experience building, managing, and mentoring toxicology teams within a collaborative, matrixed environment</li> <li>Extensive experience preparing and reviewing nonclinical sections of global regulatory submissions and engaging with health authorities (FDA, EMA)</li> <li>Strong ability to integrate complex nonclinical datasets across toxicology, pathology, DMPK, and pharmacology to inform development decisions</li> <li>Experience overseeing outsourced toxicology and safety pharmacology studies and managing CRO partnerships</li> <li>Excellent communication and influencing skills, with the ability to partner effectively across Early Development, Research, and Regulatory functions in a fast‑paced environment</li> </ul> <p><strong><span data-contrast="auto">Compensation</span></strong><span data-ccp-props="{}">&nbsp;</span></p> <p><span data-contrast="auto">The annual base salary range for this position is $320,000.00 to $350,000.00. Individual compensation within this range will be&nbsp;determined&nbsp;based on a variety of factors, including qualifications, skills, relevant experience, and job knowledge.</span><span data-ccp-props="{}">&nbsp;</span></p> <p><span data-contrast="auto">In addition to base pay, this role is eligible for a discretionary annual bonus.</span> <span data-contrast="auto">Centessa also offers a comprehensive benefits package, which includes a 401(k) plan, company-sponsored medical, dental, vision, and life insurance, generous paid time off, and a health and wellness program.</span><span data-ccp-props="{}">&nbsp;</span></p> <p><strong>Work Location</strong></p> <p><span class="TextRun SCXW146193423 BCX0" lang="EN-US" data-contrast="auto"><span class="NormalTextRun SCXW146193423 BCX0" data-ccp-parastyle="Normal (Web)">The&nbsp;</span><span class="NormalTextRun SCXW146193423 BCX0" data-ccp-parastyle="Normal (Web)">Executive Director, Head of&nbsp;</span><span class="NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW146193423 BCX0" data-ccp-parastyle="Normal (Web)">Toxicology</span><span class="NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW146193423 BCX0" data-ccp-parastyle="Normal (Web)">&nbsp;role</span><span class="NormalTextRun SCXW146193423 BCX0" data-ccp-parastyle="Normal (Web)">&nbsp;is a remote role based in the US, with occasional travel</span><span class="NormalTextRun SCXW146193423 BCX0" data-ccp-parastyle="Normal (Web)">.</span></span><span class="EOP SCXW146193423 BCX0" data-ccp-props="{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335557856&quot;:16777215,&quot;335559738&quot;:0,&quot;335559739&quot;:360,&quot;335559740&quot;:240}">&nbsp;</span></p> <p><strong>POSITION:</strong> Full-Time, Exempt</p><div class="content-conclusion"><p>EEOC Statement: Centessa Pharmaceuticals believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion, or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Centessa Pharmaceuticals will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.</p> <p><strong><span class="break-words tvm-parent-container">Please note: We will not assign referral rights for any unsolicited resumes from recruitment agencies.</span></strong></p> <p><strong><span class="break-words tvm-parent-container"><img src="https://centessa.hosted-by-files.com/CorpImages/Centessa_Pharmaceuticals_LLC_US_English_2026_Certification_Badge.png" alt="Great Place to Work Certificate" width="248" style="max-width: 100%;"></span></strong></p></div>