Principal Process Engineer, ECO Synthesis

• Possess a passion for being part of the therapeutic community helping bring cutting edge treatments to patients in need. 
• Enjoys collaboration across different functional groups to get a holistic understanding of process development along with aligning data with internal stakeholders.
• Enjoys problem solving by implementing engineering and analytical solutions. 

Key Responsibilities

• Providing technical leadership in hands‑on process development, applying advanced engineering principles to drive the design, build‑out, and maturation of the ECO Synthesis® platform in close partnership with cross‑functional development teams
• Leading the scale‑up strategy for the ECO Synthesis® platform, ensuring process is robust, well‑characterized, and ready for transition into a cGMP manufacturing environment.
• Championing laboratory safety, maintaining a clean and compliant workspace, conducting process hazard analyses and risk assessments, and ensuring safe working environment for all team members.
• Overseeing documentation quality, ensuring batch records, SOPs, and development reports meet GDP standards; providing mentorship and guidance to early‑career engineers and scientists on documentation and experimental/statistical rigor.
• Leading the development and delivery of key technical work, including internal and external presentations, detailed technical reports, and comprehensive technology transfer packages for siRNA manufacturing processes.
• Owning the creation of engineering design tools, including mass and energy balances, process flow diagrams (PFDs), equipment specifications, and cost models to support scale‑up, facility integration, and long‑term platform deployment.
• Serving as primary technical liaison with external vendors, driving equipment selection, qualification, and support activities essential for effective process development and scale‑up.

Skills, Knowledge & Expertise

Job Benefits

• Medical, Dental and Vision Insurance 
• Basic Life, AD&D, Short- and Long-Term Disability Insurance 
• 401k with Company Match up to 4% 
• Company Equity 
• Generous Paid Time Off including 18 Company Holidays (with a summer and winter shutdown), Vacation, and Wellness Time 
• Annual Lifestyle Account for reimbursement of fitness programs, equipment and more 
• Employee Stock Purchase Program (ESPP) 
• Flexible Spending Accounts (Commuter/Parking, Dependent Care & Healthcare)
• Student Debt Program (Company Contribution to Loans)
• Mental Health Wellness Program
• Subsidized onsite lunch program
• Onsite Gym Facilities
• Paid Parental Leave