Senior Research Scientist, High Throughput Biology

<p><strong>About Integrated Biosciences</strong></p> <p>At Integrated, we are focused on advancing small molecule therapeutics for age-related diseases by leveraging our first-of-its-kind discovery platform at the intersection of phenotypic models of aging, chemistry, and AI. Backed by top-tier tech VCs, and with recent publications in <em>Cell</em> (2025), <em>Nature</em> (2024), <em>Nature Aging</em> (2023), and <em>Nature Protocols</em> (2025), we’re rapidly expanding our scientific team to accelerate our growing pipeline. We are seeking a talented Senior Scientist to drive our high throughput biology efforts and help us find the next generation of small molecule therapeutics in aging.</p> <p>&nbsp;</p> <p><strong>About the Role</strong></p> <p>We’re seeking a driven and highly skilled Senior Scientist to build and execute on our high throughput biology capabilities. In this role, you will be the in-house expert on high throughput assay development and execution — designing and running biochemical and cell-based assays in 384-well format, designing and deploying liquid handling automation and robotics, and turning large compound screening datasets into clear, actionable scientific insights.</p> <p>&nbsp;</p> <p>You’ll partner closely with the rest of our biology team along with medicinal chemistry to enable every stage of small molecule discovery from primary screening through hit-to-lead and lead optimization and you’ll play a central role in shaping how we run our screening platform as the company scales.</p> <p>&nbsp;</p> <p>If you’re someone who loves the challenge of making an assay work at scale and is energized by generating and analyzing large high-quality data sets, we want to hear from you.</p> <p>&nbsp;</p> <p><strong>You will</strong></p> <p><em>Assay Development &amp; Screening</em></p> <ul> <li>Design, develop, miniaturize, and validate biochemical and cell-based assays in 384-well and higher-density formats to support primary screening, counterscreening, and selectivity profiling.</li> <li>Execute high throughput screening (HTS) campaigns against compound libraries and follow-up dose-response studies to characterize hit compounds and support hit-to-lead progression.</li> <li>Develop and optimize assays to support lead optimization cycles, including potency, selectivity, mechanism of action, and relevant cellular endpoints tied to aging biology.</li> <li>Apply rigorous assay development principles (Z’ factor, signal-to-background, coefficient of variation) to ensure robust, reproducible, and HTS-ready assay performance.</li> <li>Identify, troubleshoot, and resolve assay performance issues; continuously improve throughput and data quality across the screening platform while looking for cost savings.</li> </ul> <p><em>Lab Automation &amp; Platform Operations</em></p> <ul> <li>Operate, program, and maintain liquid handling and automation equipment including the Echo 650, Bravo, and integrated robotic workstations.</li> <li>Develop and optimize automation protocols for compound dispensing, reagent addition, plate washing, and detection to maximize throughput and minimize variability.</li> <li>Manage compound libraries and plate maps; coordinate with chemistry to ensure accurate compound tracking, dilution series, and QC for screening campaigns.</li> </ul> <p><em>Data Analysis</em></p> <ul> <li>Write and maintain Python scripts and pipelines to process, analyze, visualize, and report large-scale screening datasets, including hit identification and dose-response curve fitting.</li> <li>Maintain accurate and well-documented ELN records for all screening experiments and present to cross-functional teams and leadership.</li> </ul> <p>&nbsp;</p> <p><strong>You’re a good fit if you have (required)</strong></p> <ul> <li>PhD in biology, biochemistry, chemical biology, or a closely related field.</li> <li>3–5 years of industry experience in a drug discovery setting, with a primary focus on high throughput biology, assay development, or screening sciences.</li> <li>Demonstrated expertise in developing and running biochemical and cell-based assays in 384-well plate format for HTS and hit-to-lead.</li> <li>Hands-on experience operating and programming lab automation equipment, including acoustic dispensers (Echo 650), automated deck-based systems (Bravo), and integrated robotic liquid handling platforms.</li> <li>Proficiency in Python for data analysis and visualization, including experience building scripts or pipelines to process large, complex screening datasets.</li> <li>Strong understanding of assay quality metrics (Z’ factor, S/B, CV) and compound interference mechanisms.</li> <li>Excellent scientific communication and cross-functional collaboration skills; comfortable presenting screening results and data-driven recommendations to a mixed scientific audience.</li> <li>Comfort operating independently in a fast-paced startup environment, with the ability to prioritize and manage multiple screening campaigns simultaneously.</li> </ul> <p>&nbsp;</p> <p><strong>Bonus Points For</strong></p> <ul> <li>Experience with assay technologies highly relevant to aging or age-related disease biology, including senescence assays, mitochondrial function, proteostasis, or longevity pathway readouts.</li> <li>Experience with phenotypic or image-based screening, high content imaging (HCI), and associated image analysis workflows.</li> <li>Familiarity with cheminformatics tools and data integration with medicinal chemistry platforms.</li> <li>Comfort with cutting-edge data analysis approaches, large datasets, and a curiosity about how AI and machine learning can augment screening science.</li> </ul> <p>&nbsp;</p> <p><strong>Location &amp; Logistics</strong></p> <ul> <li>Visa sponsorship available where applicable. We’ll work with you to make it happen.</li> <li>This role will be located at Redwood LIFE in Redwood City, CA, a modern and stunning life sciences complex in the Bay Area.</li> <li>Start date: immediate.</li> <li>We are an equal-opportunity employer and strongly encourage applications from individuals of diverse backgrounds, experiences, and perspectives.</li> </ul> <p>&nbsp;</p> <p><strong>Compensation &amp; benefits</strong></p> <p>We offer a highly competitive salary, meaningful equity, and comprehensive benefits, including medical and dental coverage, company-provided lunch, 401k match, and others.</p>