Associate Scientist, Display Technologies

Key Responsibilities

• Support R&D projects advancing display technologies at BigHat that expands BigHat's antibody discovery capabilities and feed its ML models.
• Lead in the construction and QC of phage and yeast display libraries across diverse antibody formats (VHH, scFv, Fab) using standard molecular biology techniques (PCR, molecular cloning, electroporation).
• Execute phage and yeast display selections using naive and affinity and stability maturation libraries to discover and engineer antibodies with desired therapeutic properties.
• Express, purify, and characterize display-derived molecules using assays including ELISA, flow cytometry, BLI/SPR, CE-SDS, and others.
• Analyze selection results and contribute to discussions on next steps and future experimental design.
• Collaborate with BigHat’s Data Science and Machine Learning teams to inform library design and interpret selection data for model training.
• Present experimental plans and results during regular meetings with manager and science teams.
• Maintain thorough records using LIMS and electronic notebooks.

Skills Knowledge and Expertise

• BS or MS in Biochemistry, Molecular Biology, Bioengineering, or a related field.
• 4+ years of hands-on laboratory experience (academic or industry); relevant internship or research experience welcome.
• Familiarity with general molecular biology techniques (PCR, molecular cloning, gel electrophoresis).
• Exposure to antibody biology, display technologies (phage or yeast), and protein expression.
• Demonstrated ability to follow protocols carefully, troubleshoot experiments, and maintain detailed lab records.
• Effective time management and clear written and verbal communication skills.
• Collaborative, team-oriented mindset with an eagerness to learn in a fast-paced startup environment.
• Nice-to-haves include experience with flow cytometry, ELISA, or other binding assays, and familiarity with NGS or automation platforms.

Total Rewards

• Range of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived)
• Dental, and vision coverage through Guardian
• Additional well-being benefits through Nayya, OneMedical, Wagmo, Rula, and more
• 401(k) with company match 
• DTO, two weeks of company-wide shutdown, and 12 company holidays
• Paid parental leave