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About the role
<div class="content-intro"><p>Centessa Pharmaceuticals plc (Nasdaq: CNTA) new kind of pharmaceutical company with a deconstructed R&D environment that prioritizes data driven decision making led by subject matter experts. Centessa is advancing a portfolio of high conviction programs with strong biological validation.</p>
<p>Our asset-centric model offers a unique R&D logic that has been applied by single asset companies to improve productivity. This operating model has minimal centralized infrastructure, reduced hierarchy, and exclusive focus on data driven capital allocation. Our teams are uniquely incentivized to expeditiously interrogate key scientific hypotheses. We believe the asset-centric model can lead to improved success rates for programs with greater speed and modest costs.</p>
<p> </p></div><p><strong>Description of Role</strong></p>
<div>The Vice President, Global Medical Safety / Pharmacovigilance will serve as the global leader for drug safety, providing strategic vision and medical oversight across all pharmacovigilance and risk management activities. This role is responsible for leading pre- and post-marketing safety activities across all phases of clinical development (Phase I–IV) and post-approval, ensuring proactive benefit–risk assessments, regulatory compliance, and the highest standards of patient safety. The VP will drive an integrated, science-driven global safety strategy for the company’s small molecule pipeline, working closely with internal stakeholders and teams, as well as global health authorities. In addition, this role will oversee departmental operations, including organizational planning, budgeting, and the development of scalable pharmacovigilance capabilities to support a growing biotech organization.</div>
<p><strong>Key Responsibilities</strong></p>
<p><strong><span data-contrast="auto">Strategic Leadership & Oversight</span><span data-ccp-props="{}"> </span></strong></p>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="1" data-aria-level="1"><span data-contrast="auto">Develop and execute a </span><span data-contrast="auto">comprehensive pharmacovigilance (PV) strategy</span><span data-contrast="auto"> aligned with corporate objectives and regulatory expectations.</span></li>
<li data-leveltext="" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="1" data-aria-level="1">Lead <span data-contrast="auto">safety governance</span><span data-contrast="auto"> and benefit-risk management for small molecule assets across development and post-marketing.</span></li>
<li data-leveltext="" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="1" data-aria-level="1">Ensure compliance with <span data-contrast="auto">global PV regulations</span><span data-contrast="auto"> (FDA, EMA, ICH, MHRA, etc.).</span></li>
<li data-leveltext="" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="1" data-aria-level="1">Provide strategic safety input into <span data-contrast="auto">clinical trial designs, protocols, and regulatory submissions</span><span data-contrast="auto">.</span></li>
<li data-leveltext="" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="1" data-aria-level="1">Establish and oversee <span data-contrast="auto">PV partnerships, vendors, and external collaborations</span><span data-contrast="auto">.</span><span data-ccp-props="{}"> </span></li>
</ul>
<p><strong><span data-contrast="auto">Operational & Regulatory Compliance</span><span data-ccp-props="{}"> </span></strong></p>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="1" data-aria-level="1"><span data-contrast="auto">Lead the </span><span data-contrast="auto">safety surveillance and signal detection process</span><span data-contrast="auto">, ensuring timely identification and mitigation of safety risks.</span></li>
<li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="1" data-aria-level="1">Oversee the preparation and submission of <span data-contrast="auto">safety reports (e.g., DSURs, PSURs, RMPs, SUSARs, IND safety reports, 15-day alerts)</span><span data-contrast="auto">.</span></li>
<li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="1" data-aria-level="1">Ensure robust <span data-contrast="auto">case processing, signal evaluation, and risk management</span><span data-contrast="auto"> processes are in place.</span></li>
<li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="1" data-aria-level="1">Represent the company in <span data-contrast="auto">regulatory interactions</span><span data-contrast="auto"> regarding safety matters (FDA, EMA, etc.).</span><span data-ccp-props="{}"> </span></li>
</ul>
<p><strong><span data-contrast="auto">Cross-Functional Collaboration</span><span data-ccp-props="{}"> </span></strong></p>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="3" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="1" data-aria-level="1"><span data-contrast="auto">Work closely with </span><span data-contrast="auto">Clinical Development, Clinical Operations, Regulatory, Medical Affairs, and Commercial teams</span><span data-contrast="auto"> to integrate safety considerations into decision-making.</span><span data-ccp-props="{}"> </span></li>
<li data-leveltext="" data-font="Symbol" data-listid="3" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="1" data-aria-level="1">Partner with <span data-contrast="auto">Regulatory Affairs</span><span data-contrast="auto"> to support new drug applications (NDAs) and marketing authorizations.</span></li>
<li data-leveltext="" data-font="Symbol" data-listid="3" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="1" data-aria-level="1">Support <span data-contrast="auto">DSMBs, advisory boards, and investigator meetings</span><span data-contrast="auto"> with safety expertise.</span><span data-ccp-props="{}"> </span></li>
</ul>
<p><strong><span data-contrast="auto">Team Leadership & Development</span><span data-ccp-props="{}"> </span></strong></p>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="4" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="1" data-aria-level="1"><span data-contrast="auto">Build and lead a high-performing </span><span data-contrast="auto">pharmacovigilance team</span><span data-contrast="auto">, fostering a culture of scientific excellence and compliance.</span></li>
<li data-leveltext="" data-font="Symbol" data-listid="4" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="1" data-aria-level="1">Provide mentorship and guidance to internal safety professionals.<span data-ccp-props="{}"> </span></li>
</ul>
<div><strong>Qualifications </strong></div>
<div>
<ul>
<li>Medical Degree (MD) in a life science–related field is required.</li>
<li>15+ years of pharmacovigilance experience in the biopharmaceutical industry, including 10+ years in senior leadership roles.</li>
<li>Demonstrated experience supporting CNS drug development programs across clinical and post-marketing stages.</li>
<li>Extensive experience in small molecule drug development (Phase 1–Phase 4).</li>
<li>Proven track record of effective interactions with global health authorities on safety-related matters.</li>
<li>Deep understanding of global pharmacovigilance regulations, GVP, and ICH guidelines.</li>
<li>Demonstrated ability to lead safety risk management strategies, signal detection, and benefit–risk assessments.</li>
<li>Experience leading cross-functional safety teams and influencing stakeholders in a fast-paced biotech environment.</li>
<li>Expertise in clinical trial safety oversight, post-marketing pharmacovigilance, and regulatory safety submissions.</li>
<li>Strong analytical judgment, decision-making, and problem-solving capabilities.</li>
<li>Excellent written and verbal communication skills with the ability to engage senior internal and external stakeholders.</li>
<li>Ability to thrive in a dynamic, high-growth organization.</li>
</ul>
</div>
<p><strong>Compensation</strong></p>
<p>The annual base salary range for this position is $350,000.00 to $380,000.00. Individual compensation within this range will be determined based on a variety of factors, including qualifications, skills, relevant experience, and job knowledge.</p>
<p>In addition to base pay, this role is eligible for a discretionary annual bonus. Centessa also offers a comprehensive benefits package, which includes a 401(k) plan, company-sponsored medical, dental, vision, and life insurance, generous paid time off, and a health and wellness program.</p>
<p><strong>Work Location</strong></p>
<p>The Vice President, Pharmacovigilance and Safety role is based in the US, with occasional travel.</p>
<p><strong>POSITION:</strong> Full-Time, Exempt</p><div class="content-conclusion"><p>EEOC Statement: Centessa Pharmaceuticals believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion, or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Centessa Pharmaceuticals will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.</p>
<p><strong><span class="break-words
tvm-parent-container">Please note: We will not assign referral rights for any unsolicited resumes from recruitment agencies.</span></strong></p>
<p><strong><span class="break-words
tvm-parent-container"><img src="https://centessa.hosted-by-files.com/CorpImages/Centessa_Pharmaceuticals_LLC_US_English_2026_Certification_Badge.png" alt="Great Place to Work Certificate" width="248" style="max-width: 100%;"></span></strong></p></div>
Perks & benefits
- 401k
- Paid Time Off
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